Melrose Homes For Sale & Real Estate - 37 homes

Remarks: Welcome to this charming 2-bedroom, 2-bath home in the heart of Melrose. Built in 1958 with 1,156 sq ft of living space, this well-maintained property features classic terrazzo floors, an updated kitchen with stainless steel appliances, and a bright, open living area. The 1,830 sq ft total area provides extra room for relaxing or entertaining. Situated on a quiet street just minutes from downtown Melrose, local dining, grocery options, and the public boat ramp to 6,000-acre Lake Santa Fe. Enjoy small-town charm with convenient access to Gainesville, Palatka, and Keystone Heights. Move-in ready and perfectly located—experience why Melrose remains one of North Florida's most sought-after communities.

Listing is courtesy of: TREVOR WATERS REALTY INC (352-473-7777)

Listing Agent: Branden Waters (352-222-2888)

Remarks: Enjoy peaceful country living with this 3 bedroom, 2 bathroom mobile home. Sitting on over an acre lot, the mature trees and open surroundings provide a sense of privacy while maintaining easy access to nearby amenities. Located just minutes from Melrose and Lake Santa Fe, this property offers the best of rural living with convenient access to Gainesville (approximately 40 minutes) and Jacksonville and St. Augustine (just over an hour). The neighboring parcel with an additional mobile home is also available for purchase, offering a unique opportunity for extended living, investment potential, or future expansion.

Listing is courtesy of: KINGS HOME REALTY LLC (941-504-0016)

Listing Agent: Garrett King (941-504-0016)

Remarks: Come home to Florida lakefront living at its best! Welcome to the cool clear waters of Lake Lilly and this nearly new well built three bedroom and two bathroom home with stunning views. Wood lined cathedral ceilings greet you as you enter the light filled great room from the front porch with unobstructed views through the open concept dining, kitchen, and living area to the sprawling back porch and out to the covered dock. The kitchen is an entertainer's dream with a massive island, granite counters, stainless appliances, and a gas cooktop. A luxurious primary suite offers lake views, covered porch access, two walk-in closets, and a spa like bathroom with oversized shower and a walk-in soaking tub. The split floorplan includes two additional large bedrooms and a spacious bathroom. Boating is a breeze with the private ramp and covered storage complete with full 30 amp RV hookups. No detail was overlooked and no expense spared when building this lakefront retreat from the world. A solar panel system contributes to energy efficiency, and everything runs as usual during prolonged power outages thanks to the whole house generator with a 1,000 gallon in-ground propane tank. The air conditioned garage includes workshop space with stainless sinks and plenty of room to store more than cars. A carport and two sheds provide covered parking and storage near the house, and there's another by the dock for easy access to all those water toys and floats. Lake Lily is a private spring fed lake in the heart of north central Florida's lake region with easy access to Gainesville, Jacksonville, and Ocala. Nearby Melrose and Keystone offer many great dining and shopping options. Call today to see this amazing property for yourself!

Listing is courtesy of: MATCHMAKER REALTY OF ALACHUA COUNTY (352-372-3930)

Listing Agent: Tate Mikell (352-225-1871)

Remarks: Under contract-accepting backup offers. You could own almost 2 acres of beautiful rural land with lake front and a 3 bed 2 bath home ready for renovation - or remove the home and take advantage of the existing utilities for your dream home. 100 foot of lakefront with agricultural zoning, scenic mature trees, and open meadow space. Tons of potential here - bring your toolbelt, your ideas, and make this lakefront getaway everything you've been dreaming of.

Listing is courtesy of: EXP REALTY LLC (888-883-8509)

Listing Agent: Holly Alfery Beard (352-359-7084)

Remarks: Under contract-accepting backup offers. What an amazing value on this lovingly maintained 1970 mobile home that has been in the same family for decades! Conventional financing available through 21st Mortgage. 2.75 stately acres adorned with majestic live oaks await your dream garden, four-legged friends, farm animals, and more! Two massive outbuildings (one almost 1,700sqft and the other almost 1,800sqft) both have water and power. Turn one into your horse stalls and use the other for all your equipment. Plus, a newer shed with electric and metal roof is just off the rear patio for all your lawn tools. Turn it into storage or a workshop! The covered outdoor pavilion is the perfect place to relax with friends, BBQ, or enjoy a peaceful cup of coffee in the morning. When it is a little too chilly for outdoor sitting, the oversized attached Florida room has you covered! All of this while still being just minutes from all the conveniences of town. Plus, you're just 10 minutes away from the almost 6,000-acre Lake Santa Fe with its park and public boat ramp. Welcome Home!

Listing is courtesy of: EPIQUE REALTY, INC. (888-893-3537)

Listing Agent: Walter Key (757-635-3645)

Remarks: Under contract-accepting backup offers. 5 acre homestead featuring a remodeled 2 bedroom 2 bath single wide in a fantastic location just minutes outside Melrose. Tile, wood and laminate flooring throughout.  Established food and medicinal plant forest where mulberry, fig, pear, banana, elderberry, camphor, grape, citrus, turmeric, galangal ginger, sweet potato, pumpkin and more can be found. Additionally, various animal shelters, fencing, and a 250 gallon rainwater catchment system support your homesteading endeavors.  The insulated and air conditioned studio cabin is suitable for Airbnb, additional housing, or home office. The additional large shed provides space for your tools and equipment.

Listing is courtesy of: PROPERTUNITY REAL ESTATE PROS (386-243-8316)

Listing Agent: Brian Hetzer (352-900-3810)

Remarks: Tucked away at the very end of Island Road, this charming rustic retreat offers a rare opportunity to enjoy true waterfront living on the Santa Fe Canal—just steps from where it opens into Lake Santa Fe. This 3-bedroom, 2-bath home blends cozy character with thoughtful updates, including a beautifully refreshed kitchen and bathrooms, along with a durable new metal roof for peace of mind. Inside, you’ll find warm, inviting spaces that make you feel right at home from the moment you walk in. Out back is where this property truly shines. A massive Florida room creates the ultimate entertaining space—complete with a built-in bar area and pool table—perfect for hosting friends, game nights, or simply relaxing after a day on the water. Even better, all furnishings can stay, making this a turnkey opportunity. Step outside and take in peaceful canal views from your backyard, with direct access to Lake Santa Fe just moments away. As the last home before the canal opens to the lake, you’ll enjoy a unique blend of privacy and prime positioning for boating, fishing, and waterfront living. Additional features include a large workshop with electric—ideal for hobbies, storage, or projects—and a newer dock ready for your boat and lake days. Whether you’re looking for a full-time residence, weekend getaway, or income-producing vacation rental, this one-of-a-kind property delivers the best of North Florida lake life.

Listing is courtesy of: CB ISAAC REALTY (352-475-2199)

Listing Agent: Calee Hinson (386-406-0119)

Remarks: Under contract-accepting backup offers. Investor Opportunity! two charming quintessential cabins on Lake Geneva one cabin has two bedrooms and two baths with a large screen porch overlooking the lake and the 2nd cabin has one bedroom 1 bath Both have been updated a shared easement with the home up This could be a great family retreat or turn this property into an Airbnb. Great for Gator games or all the activities in Melrose! no HOA! lower taxes in Clay County.

Listing is courtesy of: FLORIDA HOMES REALTY & MORTGAGE GVILLE (352-240-1133)

Listing Agent: Deirdre Murphy (352-281-3026)

Remarks: Welcome to your slice of North Florida charm in Melrose, Florida! This well-maintained 3-bedroom, 2-bathroom home sits on a desirable corner lot, offering added space, privacy, and curb appeal. Step inside to find a comfortable and inviting layout designed for everyday living. Whether you're relaxing at home or hosting guests, this property provides the perfect balance of functionality and warmth. One of the standout features is the deeded access to the highly sought-after Swan Lake—just a short golf cart ride away. Spend your days enjoying boating, fishing, or soaking in peaceful lake views, all without the premium price of direct waterfront. Located in the heart of Melrose, you’ll love the small-town feel while still being conveniently positioned between Gainesville and Palatka. If you’ve been searching for affordable lake-area living with access to one of the region’s most desirable lakes—this is it.

Listing is courtesy of: CB ISAAC REALTY (352-475-2199)

Listing Agent: Calee Hinson (386-406-0119)

Remarks: Charm, warmth, and elegance define this beautiful pool and lake home designed for relaxed Florida living. Featuring soaring 10-foot ceilings and a spacious layout, this exceptionally well-maintained home offers stunning views of the pool, lake, and private backyard the moment you enter. The new roof (2026) includes GAF's top-tier transferable warranty, along with a recent HVAC system for added comfort and efficiency. Enjoy the pool year-round with a recent oversized Pentair pool heater. The spacious living room features a wood-burning fireplace, while the kitchen offers abundant wood cabinetry and granite countertops. Additional features include a GenerLink transfer switch installed by Clay Electric, 2-car garage, water softener, and a 19'x11' aluminum shed with electric. Situated on 2.48 beautifully wooded acres, the property is accessed by a scenic driveway providing privacy from the road.

Listing is courtesy of: TREVOR WATERS REALTY INC (352-473-7777)

Listing Agent: Branden Waters (352-222-2888)

Remarks: Well-maintained triple-wide mobile home located in Ashley Lake Plantation on 1.02 acres with AG zoning, offering 2,150 square feet of heated and cooled living space. This spacious 4-bedroom, 3-bath home features an open island kitchen with stainless steel appliances, a pantry, and an inside laundry room. A versatile bonus room adjacent to the primary suite is perfect for a home office or flex space. Relax in the family room with a cozy fireplace and enjoy peaceful water views. Roof replaced in 2019. Oversized shed/workshop with ramp access, perfect for storage, hobbies, or workspace needs. Open interior offers flexible use for equipment, tools, or recreational gear. Great functional space with easy access. Conveniently located near historic downtown Melrose and Lake Santa Fe, with an easy commute to Gainesville and Palatka. Schedule your tour today!

Listing is courtesy of: CENTURY 21 LAKESIDE REALTY (352-475-1269)

Listing Agent: Trey Fields, Iii (352-222-9251)

Remarks: Step back in time while enjoying modern possibilities with this beautifully preserved historic home, originally built in 1885 by Henry Baldwin of Naugatuck, Connecticut. Nestled in the heart of picturesque Melrose, Florida, this two-story residence offers a rare blend of heritage, charm, and versatility.Featuring 4 bedrooms and 2.5 bathrooms, the home boasts classic architectural details and inviting living spaces filled with warmth and character. Relax and unwind on the front or back porches, perfect for enjoying Florida’s tranquil surroundings, morning coffee, or evening gatherings.The property also includes a quaint metal-roofed workshop, brimming with potential—easily convertible into a charming guest cottage, studio, or creative retreat. There is also another small out building perfect for storage.Adding to its appeal, the property is zoned for home-based business use, offering a unique opportunity. Operate your business right from home, with the convenience of on-site work permitted as long as the owner resides on the property. Melrose is a small town with lots of charm. Boasting only one traffic light but twice as many art galleries and several lakes available for swimming, boating and other water activities. Melrose is also located 20 minutes from the city of Gainesville, home of the University of Florida and all that comes with a college town. Whether you're seeking a distinctive residence, a live/work opportunity, or a piece of Florida history, this property offers endless possibilities.

Listing is courtesy of: CENTURY 21 LAKESIDE REALTY (352-475-1269)

Listing Agent: Teri Sapp (352-494-3724)

Remarks: Lakefront living with built-in income potential! This well-maintained home sits on a landscaped 1.19-acre high and dry lot in a quiet neighborhood just minutes from downtown historic Melrose. 3 bedrooms, 3 full bathrooms (main residence is 2 bed / 2 bath), an open flow, tons of storage, and a fully screened patio w/ hot tub. Additionally, there is a 900-sqft semi-finished basement with drywall, electrical, and plumbing. Use it for massive storage, finished into a private office space, etc. Separate storage area for lawn mowers and yard tools plus a 1-car garage and ample additional driveway parking. A full efficiency apartment with kitchen and full bathroom is currently rented for almost $1,000/MO on a short-term lease. Perfect for passive income, the perfect in-law suite, or a guesthouse. All of this in a prime location less than 30 minutes to Gainesville and just 5 minutes up the road to the almost 6,000-acre Lake Sante Fe public boat launch! Seller financing possible. Welcome Home!

Listing is courtesy of: EPIQUE REALTY, INC. (888-893-3537)

Listing Agent: Walter Key (757-635-3645)

Remarks: Located near the historic town of Melrose, this spacious 3-bedroom, 3-bath home sits on over 1.23 acres of lush and peaceful landscape. Deeded Access to Melrose Bay includes a 25ft easement with dock for access to Lake Santa Fe to enjoy beautiful views, fishing and kayaking. You are walking distance to small town charm to enjoy art galleries, restaurants, and parks. Open floor plan with lots of natural lighting. Kitchen is spacious and is open to a sunroom with nice built-ins. Nice Terrazzo flooring in main arears of the home are hidden under carpet! With generous living spaces and an ideal location, this home is a rare opportunity to enjoy both comfort and the vibrant lifestyle of downtown Melrose.

Listing is courtesy of: CB ISAAC REALTY (352-475-2199)

Listing Agent: Ronald Blake (352-235-1644)

Remarks: DIRECT LAKEFRONT- Lake Santa Fe, is rated one of the BEST natural spring fed lakes in Florida. Welcome Home to your dream family lake house! Nestled on a tranquil lot with panoramic water views, this stunning lakefront home is designed for both relaxation and entertaining. With its spacious living areas, it’s the perfect place to create unforgettable memories. The fully furnished main home features 3 generous bedrooms and 3.5 bathrooms, an open-concept kitchen and living room flowing onto a screened-in porch with stunning lake views. Upstairs you will find 2 large bedrooms, each with ensuite bathrooms along with a cozy second living area- ideal for guests. This property also features an oversized 3-car garage with ample storage for boats and lake gear. Above the garage you will find a fully finished 1-bedroom, 1-bathroom guest apartment with a full kitchen and living room- perfect for extended family, visitors, or Airbnb potential. This beautiful home sits on 0.69 areas, designed for outdoor enjoyment and easy lake access, less than a mile from the boat ramp with plenty of space to park a boat or RV. Enjoy your days on the lake or enjoying the two screened-in porches to soak in the lake breeze. This home isn’t just a property—it’s a lifestyle. Enjoy sun-soaked days by the water, evenings under the stars, and every special moment in between. Whether you're looking for a full-time residence or a weekend escape, this lakefront gem offers everything you need and more. This Amazing location is only 25 minutes to Gainesville, 5 minutes to downtown Melrose and 15 minutes to Keystone Heights. Big Lake Santa Fe is a 5800 acre, aquifer fed stable lake with amazing fishing, recreation and water sports. Come for the views and stay for the peace and relaxation in this turnkey lakefront home! While all information is believed to be accurate, measurements should be verified by potential buyers

Listing is courtesy of: MG REAL ESTATE GROUP (386-314-9502)

Listing Agent: Skye Chapman (904-234-2755)

Remarks: Enjoy lakefront living on peaceful Lake Serena (approximately 60 acres). Set on a beautiful ~0.25-acre lot shaded by majestic oaks and blooming azaleas, this well-kept 1970 single-wide mobile home offers 3 bedrooms and 1.5 baths with a practical, easy-living layout. Step onto the back deck for sweeping water views—perfect for morning coffee or sunset unwinding. Spend time in the gazebo enjoying the vistas, or lay back in the hammock and take a cat nap. Fenced backyard includes a storage shed for your gear and garden tools, while the front yard features a powered 225-sq-ft block building—great for a workshop, studio, or extra storage. With direct lake access for paddling, fishing, and relaxing, this home delivers a laid-back lifestyle and a hard-to-find price point on the water. Bring your ideas to personalize, or enjoy as is—either way, you're buying into true lake life.

Listing is courtesy of: IHEART REALTY INC. (386-546-8571)

Listing Agent: Heather Hunter (386-283-3343)

Remarks: Tucked along the peaceful shores of Melrose Bay on Lake Santa Fe, 715 Seminole Ridge Road is a private lakefront retreat offering nearly 5,500 square feet of conditioned living space on 1.36 acres. Set along a gently rolling hillside, the property captures expansive lake views and the relaxed rhythm of waterfront living. The main residence offers four bedrooms and multiple inviting living spaces designed for both connection and quiet retreat. A spacious living room, adjacent dining area, and dedicated Florida room provide comfortable gathering spaces, while two fireplaces add warmth and character throughout the home. The main living areas feature updated faux-wood ceramic tile flooring, offering the warmth of wood with the durability of tile while providing a cohesive flow throughout the home. Well-appointed and recently renovated by Haile Kitchen & Bath, this stunning kitchen features custom wood cabinetry, expansive quartz counters, and a KitchenAid stainless steel appliance package. A thoughtful three-way split floor plan provides privacy and flexibility. One bedroom enjoys its own full bath, while two additional bedrooms share a beautifully renovated Jack-and-Jill bathroom. The upstairs primary suite offers a peaceful escape with stunning lake views, a comfortable sitting area, elegant ensuite bath, and generous walk-in closet. Just steps away, the guest house offers two bedrooms, two full baths, a full kitchen, living room, and dining area—ideal for long term guests or multigenerational living. Outdoor living truly defines the experience here with an expansive screened porch overlooking the lake, a screen-enclosed pool and spa, and a fully equipped summer kitchen featuring a premium professional-grade grill, Big Green Egg smoker, custom cabinetry and granite counters. The gently sloping lawn leads to the screened boathouse and private dock constructed with low-maintenance, long-life Trex composite decking material. A new covered boat lift and lakeside kitchen make it easy to transition from a day on the water to relaxed evenings overlooking Melrose Bay and the open waters of Big Lake Santa Fe. Additional features include a whole house, fully automatic Generac propane generator serving the main residence and a two-car garage with the potential to convert to a three-car configuration. Located in one of the most desirable areas of Lake Santa Fe, Melrose Bay is known for its natural beauty and protected shoreline as a no-wake zone, offering calm waters and a peaceful lakeside setting.

Listing is courtesy of: COLDWELL BANKER M.M. PARRISH REALTORS (352-335-4999)

Listing Agent: Jim Doxey (352-215-3266)