Melrose Single Family Homes For Sale - 23 homes

Remarks: DIRECT LAKEFRONT- Lake Santa Fe, is rated one of the BEST natural spring fed lakes in Florida. Welcome Home to your dream family lake house! Nestled on a tranquil lot with panoramic water views, this stunning lakefront home is designed for both relaxation and entertaining. With its spacious living areas, it’s the perfect place to create unforgettable memories. The fully furnished main home features 3 generous bedrooms and 3.5 bathrooms, an open-concept kitchen and living room flowing onto a screened-in porch with stunning lake views. Upstairs you will find 2 large bedrooms, each with ensuite bathrooms along with a cozy second living area- ideal for guests. This property also features an oversized 3-car garage with ample storage for boats and lake gear. Above the garage you will find a fully finished 1-bedroom, 1-bathroom guest apartment with a full kitchen and living room- perfect for extended family, visitors, or Airbnb potential. This beautiful home sits on 0.69 areas, designed for outdoor enjoyment and easy lake access, less than a mile from the boat ramp with plenty of space to park a boat or RV. Enjoy your days on the lake or enjoying the two screened-in porches to soak in the lake breeze. This home isn’t just a property—it’s a lifestyle. Enjoy sun-soaked days by the water, evenings under the stars, and every special moment in between. Whether you're looking for a full-time residence or a weekend escape, this lakefront gem offers everything you need and more. This Amazing location is only 25 minutes to Gainesville, 5 minutes to downtown Melrose and 15 minutes to Keystone Heights. Big Lake Santa Fe is a 5800 acre, aquifer fed stable lake with amazing fishing, recreation and water sports. Come for the views and stay for the peace and relaxation in this turnkey lakefront home! While all information is believed to be accurate, measurements should be verified by potential buyers

Listing is courtesy of: MG REAL ESTATE GROUP (386-314-9502)

Listing Agent: Skye Chapman (904-234-2755)

Remarks: Adorable 3 bedroom 2 bath home in Seminole Ridge with access to Lake Santa Fe with membership! Just grab your kayak and walk across the way to paradise! Open floor plan for a spacious feel for entertaining. Solid surface counters, Indoor laundry with utility sink. Kitchen includes a double pantry with lots of cabinet space. Master suite with beautiful walk-in shower with double sinks. Great neighborhood perfect for first time home buyers or retired couple

Listing is courtesy of: CB ISAAC REALTY (352-475-2199)

Listing Agent: Ronald Blake (352-235-1644)

Remarks: Tucked along the peaceful shores of Melrose Bay on Lake Santa Fe, 715 Seminole Ridge Road is a private lakefront retreat offering nearly 5,500 square feet of conditioned living space on 1.36 acres. Set along a gently rolling hillside, the property captures expansive lake views and the relaxed rhythm of waterfront living. The main residence offers four bedrooms and multiple inviting living spaces designed for both connection and quiet retreat. A spacious living room, adjacent dining area, and dedicated Florida room provide comfortable gathering spaces, while two fireplaces add warmth and character throughout the home. The main living areas feature updated faux-wood ceramic tile flooring, offering the warmth of wood with the durability of tile while providing a cohesive flow throughout the home. Well-appointed and recently renovated by Haile Kitchen & Bath, this stunning kitchen features custom wood cabinetry, expansive quartz counters, and a KitchenAid stainless steel appliance package. A thoughtful three-way split floor plan provides privacy and flexibility. One bedroom enjoys its own full bath, while two additional bedrooms share a beautifully renovated Jack-and-Jill bathroom. The upstairs primary suite offers a peaceful escape with stunning lake views, a comfortable sitting area, elegant ensuite bath, and generous walk-in closet. Just steps away, the guest house offers two bedrooms, two full baths, a full kitchen, living room, and dining area—ideal for long term guests or multigenerational living. Outdoor living truly defines the experience here with an expansive screened porch overlooking the lake, a screen-enclosed pool and spa, and a fully equipped summer kitchen featuring a premium professional-grade grill, Big Green Egg smoker, custom cabinetry and granite counters. The gently sloping lawn leads to the screened boathouse and private dock constructed with low-maintenance, long-life Trex composite decking material. A new covered boat lift and lakeside kitchen make it easy to transition from a day on the water to relaxed evenings overlooking Melrose Bay and the open waters of Big Lake Santa Fe. Additional features include a whole house, fully automatic Generac propane generator serving the main residence and a two-car garage with the potential to convert to a three-car configuration. Located in one of the most desirable areas of Lake Santa Fe, Melrose Bay is known for its natural beauty and protected shoreline as a no-wake zone, offering calm waters and a peaceful lakeside setting.

Listing is courtesy of: COLDWELL BANKER M.M. PARRISH REALTORS (352-335-4999)

Listing Agent: Jim Doxey (352-215-3266)